![]() ![]() Inflammation is the body’s natural and essential response to signals arising from tissue damage or pathogenic infection 1. We conclude by discussing the challenges and opportunities for biomaterial innovations in addressing inflammation. Furthermore, nanoscale platforms can deliver anti-inflammatory agents to inflammation sites. ![]() Materials can also be designed to prevent adhesive interactions of leukocytes and endothelial cells that initiate inflammatory responses. ![]() Biomaterials can be engineered to scavenge danger signals, such as reactive oxygen and nitrogen species and cell-free DNA, in the early stages of inflammation. In this Review, we first outline key elements and stages of the inflammatory environment and then discuss the design of biomaterials for different anti-inflammatory therapeutic strategies. The efficacy of anti-inflammatory drugs, developed for the treatment of dysregulated inflammation, can be potentiated using biomaterials, by improving the bioavailability of drugs and by reducing side effects. Dysregulated inflammatory responses occur in many diseases, including cancer, sepsis and autoimmunity. Inflammation plays an important role in the response to danger signals arising from damage to our body and in restoring homeostasis. ![]()
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